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      近年来,随着分子生物技术的快速发展,液体活检凭借其便捷、无创、克服肿瘤异质性、动态监测和提供监测信息全面等优势迅速成为了肿瘤诊疗领域人们持续关注的焦点,在肿瘤早筛、预后判断、用药指导和动态监测方面有着巨大的研究潜力、临床应用前景和商业价值。中德两国是推动肿瘤个体化诊疗发展的重要力量,两国专家在液体活检基础研发、临床研究和临床实践等方面有着众多具有影响力的创新和突破。2019年3月1-4日在上海市第一人民医院南院会议中心举办的以“ 肿瘤液体活检及精准治疗:突破与发展”为主题的中德双边论坛,将邀请40余位相关领域知名专家分享液体活检技术研发和临床应用研究经验,展望前景。内容主要涉及液体活检在精准医疗中的应用、CTCs/DTCs在血液和肿瘤转移病灶中的检测与动态监测、CDX模型构建、组学研究及其特异性生物标记物鉴定、CTCs/DTCs异质性、单细胞组学技术进展(基因、转录组、表观遗传组学及代谢组学)、外泌体体内分泌与标记技术、线粒体DNA等新型标记物在肿瘤早筛/预后判断和用药监测的探索等精彩议题。

      我们诚挚地邀请您参加本次大会,在交流碰撞中,拓宽加深对液体活检技术的认知,推动癌症研究技术、方法创新,促进该领域的合作进展。本次论坛为国家继续教育项目,可获得Ⅱ类学分。

      期待在上海见到你!

大会组委会

2018年12月23日


会议日程

Sino-German Symposium on: “Understanding the metastatic progression: Liquid biopsies and therapeutic targets in systemic cancer”
2019年03月01日 14:00-22:00签到 (March 1st 14:00-22:00 Sign in)
March 2nd Morning Chairs: Olivier Gires and Hongxia Wang
08:00-08:30 Sign in and take photograph
08:30-09:00 Opening Speech by President of Shanghai General Hospital, representative from Germany, Profs. Olivier Gires and Hongxia Wang; Take a group photograph
Chairs: Xiangdong Wang (王向东) Nikolas H. Stoecklein
09:00-09:25 Harriet Wikman Circulating tumor cells, Detection, Biology and Clinical Applications Hamburg, Germany
09:25-09:50 张志谦 (Zhiqian Zhang) The prognostic value of voltage-gated calcium channel α2δ1 in liver cancer (Peking University Cancer Hospital) 北京大学肿瘤医院
09:50-10:00 Discussion
Chairs: Hongxia Wang(王红霞) Harriet Wikman
10:00-10:25 邢金良 (Jinliang Xing) Mitochondrial DNA mutation as potential new tumor biomarker (Fourth Military Medical University) 第四军医大学
10:25-10:50 王树涛 (Shutao Wang) Engineering biointerface with controlled cell adhesion towards cancer diagnostics (Chinese Academy of Sciences) 中国科学院
10:50-11:00 Discussion
11:00-11:25 Olivier Gires EMT in systemic metastatic breast cancer cells Munich, Germany
11:25-11:35 Discussion
Lunch
March 2nd Afternoon
Chairs: Ceshi Chen(陈策实) Olivier Gires
13:00-13:25 王向东 (Xiangdong Wang) Lipidomic profiles in lung diseases Fudan University(复旦大学)
13:25-13:50 陈策实 (Ceshi Chen) MiR153 inhibits breast cancer cell stem cells and angiogenesis (Chinese Academy of Sciences) 中国科学院
13:50-14:00 Discussion
Chairs: Leizhen Zheng (郑磊贞) Unger Kristian
14:00-14:25 Christoph Reichel The NLRP3 inflammasome drives neutrophil trafficking and tumor progression in breast cancer Munich, Germany
14:25-14:50 陈洛南 (Luonan Chen) Network biomarkers and dynamic network biomarkers (Chinese Academy of Sciences) 中国科学院
14:50-15:00 Discussion
Chairs:Luonan Chen(陈洛南) Basant Kumar Thakur
15:00-15:25 Nikolas H. Stoecklein Diagnostic Leukapheresis to enhance CTC-based liquid biopsies Dusseldorf, Germany
15:25-15:50 Nuh N. Rahbari Liquid biopsies to guide therapeutic decision-making in metastatic colorectal cancer Mannheim, Germany
15:50-16:15 于文强 (Wenqiang Yu) Cancer Specific DNA Methylation Detection and its Application in Liquid biopsy Fudan University(复旦大学)
16:15-16:30 Discussion
Social evening
March 3rd Morning
Chairs:Jinliang Xing(邢金良) Ingeborg Tinhofer-Keilholz
08:30-08:55 Constantin Pixberg Methylation patterns of EMT-associated genes in single circulating tumor cells Heidelberg, Germany
08:55-09:20 古宏晨 (Hongchen Gu) Multiple and sensitive identification of ctDNA based on Liquidchip Shanghai Jiaotong University(上海交通大学)
09:20-09:30 Discussion
Chairs: Zhiyuan Hu(胡志远) Wolfgang Janni
09:30-09:55 胡志远 (Zhiyuan Hu) Circulating tumor cells (CTCs) as predictive and surveillance biomarker for PD-1/PD-L1 drug efficacy The National Center for Nanoscience and Technology (国家纳米科学中心)
09:55-10:20 Unger Kristian Prognostic models in glioblastoma and head and neck squamous cell carcinoma Munich, Germany
10:20-10:30 Discussion
Chairs:Fengchun Zhang (张凤春) Nuh Rahbari
10:30-10:55 钱昆 (Kun Qian) Design of omic platforms for diagnostic application Shanghai Jiaotong University(上海交通大学)
10:55-11:20 刘强(Qiang Liu) A large NGS panel identifies circulating tumor DNA that predicts the response and prognosis in early breast cancer patients receiving neoadjuvant chemotherapy (Sun Yat-sen Memorial Hospital, Sun Yat-Sen University) 孙逸仙纪念医院
11:20-11:30 Discussion
Lunch
March 3rd Afternoon
Chairs: Zhiqian Zhang (张志谦) Ulrich Keilholz
13:00-13:25 施奇惠 (Qihui Shi) Identification, single-cell sequencing and clinical applications of circulating tumor cells Fudan University(复旦大学)
13:25-13:50 Wolfgang Janni Clinical Utility of CTC Detection in Breast Cancer Ulm, Germany
13:50-14:00 Discussion
Chairs:Xing Sun (孙星) Christoph A Reichel
14:00-14:25 Ingeborg Tinhofer-Keilholz Molecular profiles of circulating tumor cells as biomarkers for treatment selection Berlin, Germany
14:25-14:50 谢鹭 (Lu Xie) The identification of metabolic biomarkers by multi-omics data integration Shanghai Bioinformatics Research Center (上海生物信息技术研究中心)
14:50-15:00 Discussion
Chairs: Jinfei Chen (陈锦飞) Constantin Pixberg
15:00-15:25 石铁流 (Tieliu Shi) Integrative analysis identifies potential DNA methylation biomarkers for pan-cancer diagnosis and prognosis East China Normal University(华东师范大学)
15:25-15:50 Basant Kumar Thakur DNA in extracelullar vesicles (exosome): biomarker and functional potential in cancer and metastasis Essen, Germany
15:50-16:00 Discussion
Chairs:Wenqiang Yu (于文强) Roman Nawroth
16:00-16:25 Roman Nawroth Mechanisms of resistance and strategies for combination therapies to CDK4/6 inhibition in bladder cancer Munich, Germany
16:25-16:50 陈锦飞 (Jingfei Chen) Liquid biopsy in gastric cancer Nanjing Medical University (南京医科大学)
16:50-17:00 Discussion
Dinner
March 4rd Morning
Chairs:Leichen (陈磊) Hans Neubauer
08:30-08:55 Christian Werno Development and characterization of preclinical models from disseminated and circulating tumor cells Regensburg, Germany
08:55-09:20 陈翔 (Xiang Chen) Multi-sensitivity identification of ctDNA based on liquid chip Shanghai Jiao Tong University (上海交通大学)
09:20-09:30 Discussion
Chairs:Xiang Chen(陈翔) Christian Werno
09:30-09:55 Hans Neubauer Lessons from an index patient with high burden of CTCs Dusseldorf, Germany
09:55-10:20 陈磊 (Lei Chen) The Application of Liquidbiopsy for Survellience and Diagnosis of very Early Stage Hepatocellular Carcinoma Shanghai Eastern Hepatobiliary hospital (上海东方肝胆医院)
10:20-10:30 Discussion
Chairs:Shutao Wang(王树涛) Nikolas Stoecklein
10:30-10:55 宓现强 (Xianqiang Mi) Microfluidic detection system combined with nanotechnology for cancer liquid biopsy Chinese Academy of Sciences (中国科学院)
10:55-11:20 Ulrich Keilholz Charité Precision Medicine Program Berlin, Germany
11:20-11:45 孙英丽(Yingli Sun) Application of liquid biopsy in cancer research Chinese Academy of Sciences (中国科学院)
11:45-11:50 Discussion
11:50-12:00 Closing remarks by Profs. Olivier Gires and Hongxia Wang
Lunch
March 5rd Morning
Bi-lateral exchanges and lab visits